Trying to cleanup botanical matrix is not a slam dunk ! Trace level pesticide analysis requires preservation of compounds -removing interferences without too many steps is extremely challenging aspect but necessary. Want to thank UCT for all the donations of SPE, dSPE and Quechers. Was able to try a few approaches-dSpe, C18 passthroughs, cleanup DPX tips, Quechers, and Spinfiltr (mixed blend of spe materials). Not one method 100% worked - but combination methods appeared to show the best results for select pesticides. This is just a snapshot but definitely have a goal of performing experiments that address an unmet need in over all cleanup goals.